AstraZeneca PLC - SEC Filing
The information on this page is updated via a feed from the London Stock Exchange's Regulatory News Service.
Close | Print



  
    
    
    
    
 
 
As filed with the Securities and Exchange Commission on ___________ ___, 2008
Registration No. 333-______


SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

FORM S-8
REGISTRATION STATEMENT UNDER
THE SECURITIES ACT OF 1933

ASTRAZENECA PLC
(Exact Name of Registrant as Specified in its Charter)
 
ENGLAND
 
 
NONE
 
(State or Other Jurisdiction of
Incorporation or Organization)
 
(I.R.S. Employer
Identification No.)
 
 
15 Stanhope Gate
London W1K 1LN
ENGLAND
 
 
 
(Address of Principal Executive Offices)
 

ASTRAZENECA SHARE OPTION PLAN
ASTRAZENECA RESTRICTED SHARE PLAN
ASTRAZENECA PERFORMANCE SHARE PLAN
ASTRAZENECA DEFERRED BONUS PLAN
ASTRAZENECA PHARMACEUTICALS LP 2007 RESTRICTED STOCK UNIT AWARD PLAN
ASTRAZENECA PHARMACEUTICALS LP EXECUTIVE PERFORMANCE SHARE PLAN
MEDIMMUNE, INC. 2008 RESTRICTED STOCK UNIT AWARD PLAN
(Full Title of the Plan)

 
 
Ann Booth-Barbarin, Esq.
AstraZeneca Pharmaceuticals LP
1800 Concord Pke, P.O. Box 15437
Wilmington, DE 19850-5437
(302) 886-3000
 
 
 
 
(Telephone Number, Including Area Code, of Agents for Service)

With a copy to:
 
 
George R. Ince, Jr.
Davis Polk & Wardwell
450 Lexington Avenue
New York, NY 10017
(212) 450-4000
 

 
CALCULATION OF REGISTRATION FEE
Title of Each Class of Securities to be Registered
Amount To Be
 Registered(1)
Proposed Maximum
Offering Price
Per Share(2)
Proposed
 Maximum Aggregate Offering Price(2)
Amount of
Registration Fee(3)
American Depositary Receipts representing Ordinary Shares, par value £0.25 each of AstraZeneca PLC
58,195,000
$46.98 (2)
$2,734,001,100 (2)
$107,446.24
 
(1)
This Registration Statement on Form S-8 (the “Registration Statement”) covers ADRs representing Ordinary Shares of AstraZeneca PLC (the “Company” or the “Registrant”) (i) issuable pursuant to the AstraZeneca Share Option Plan, Restricted Share Plan, Performance Share Plan, Deferred Bonus Plan, Pharmaceuticals LP Executive Performance Share Plan, Pharmaceuticals LP 2007 Restricted Stock Unit Award Plan and MedImmune, Inc. 2008 Restricted Stock Unit Award Plan (the “Plans”), (ii) to be issued in the future under the Plans and (iii) pursuant to Rule 416(a) under the Securities Act of 1933, as amended (“Securities Act”), any additional ADRs that become issuable under the plans by reason of any stock dividend, stock split, or other similar transaction.
 
(2)
Estimated pursuant to Rule 457(h) and Rule 457(c) under the Securities Act, solely for the purpose of computing the registration fee, based on the average of the high and low prices reputed for a share of Common Stock on the New York Stock Exchange on July 30, 2008.  This includes shares of Common Stock to be issued upon settlement of restricted stock units granted and outstanding under the Plans.
 
(3)
Rounded up to the nearest penny.
 



PART I
 
The information specified in Item 1 and Item 2 of Part I of the Registration Statement is omitted from this filing in accordance with the provisions of Rule 428 under the Securities Act and the introductory note to Part I of the Registration Statement.  The documents containing the information specified in Part I will be delivered to the participants in the Plans as required by Rule 428(b)(1).
 
PART II
 
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
 
Item 3.  Incorporation of Documents by Reference.
 
The following documents are incorporated herein by reference:
 
(a)     Annual Report on Form 20-F for the year ended December 31, 2007 of the registrant, filed pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934 (“Exchange Act”).
 
(b)     The description of the Company’s Ordinary Shares of £0.25 each, and American Depositary Receipts evidencing American Depositary Shares, each American Depositary Share representing one Ordinary Share of the Company from Item 1 of the Form 8A/A registration statement of the Company filed under the Exchange Act (File No. 1-11960) (incorporated herein by reference).
 
In addition, all documents subsequently filed by the Company pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective amendment to this Registration Statement which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference in the Registration Statement and to be a part hereof from the date of the filing of such documents.
 
Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein, (or in any other subsequently filed document which also is incorporated or deemed to be incorporated by reference herein), modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.
 
Item 4.  Description of Securities.
 
Not applicable.
 
Item 5.  Interests of Named Experts and Counsel.
 
None.
 
Item 6.  Indemnification of Directors and Officers.
 
Article 134 of the Articles of Association of the Company provides:
 
     “Subject to the provisions of the Companies Acts but without prejudice to any indemnity to which a director may otherwise be entitled, every director or other officer of the Company shall be indemnified out of the assets of the Company against any liability incurred by him in defending any proceedings, whether civil or criminal, in which judgment is given in his favour (or the proceedings are otherwise disposed of without any finding or admission of any material breach of duty on his part) or in which he is acquitted or in connection with any application in which relief is granted to him by the court from liability for negligence, default, breach of duty or breach of trust in relation to the affairs of the Company.”
 
Article 88.2 of the Articles of Association of the Company provides:
 
2

 
     “Without prejudice to the provisions of Article 134, the board may exercise all the powers of the Company to purchase and maintain insurance for or for the benefit of any person who is or was:
 
     (a) a director, officer, employee or auditor of the Company, or any body which is or was the holding company or subsidiary undertaking of the Company, or in which the Company or such holding company or subsidiary undertaking has or had any interest (whether direct or indirect) or with which the Company or such holding company or subsidiary undertaking is or was in any way allied or associated; or
 
     (b) a trustee of any pension fund in which employees of the Company or any other body referred to in Article 88.2(a) is or has been interested,
 
including without limitation insurance against any liability incurred by such person in respect of any act or omission in the actual or purported execution or discharge of his duties or in the exercise or purported exercise of his powers or otherwise in relation to his duties, powers, or offices in relation to the relevant body or fund.”
 
     The following sections are excerpted from the United Kingdom Statute, Companies Act 1985, as amended:
 
      “Part IX, § 309A: Provisions protecting directors from liability.
 
     (1) This section applies in relation to any liability attaching to a director of a company in connection with any negligence, default, breach of duty or breach of trust by him in relation to the company.
 
     (2) Any provision which purports to exempt (to any extent) a director of a company from any liability within subsection (1) is void.
 
     (3) Any provision by which a company directly or indirectly provides (to any extent) an indemnity for a director of –
 
     (a) the company, or
 
     (b) an associated company,
 
against any liability within subsection (1) is void
 
     This is subject to subsections (4) and (5).
 
     (4) Subsection (3) does not apply to a qualifying third party indemnity provision (see section 309B(1)).
 
     (5) Subsection (3) does not prevent a company from purchasing and maintaining for a director of –
 
     (a) the company, or
 
     (b) an associated company,
 
insurance against any liability within subsection (1).
 
     (6) In this section –
 
“associated company”, in relation to a company (“C”), means a company which is C’s subsidiary, or C’s holding company or a subsidiary of C’s holding company;
 
“provision” means a provision of any nature, whether or not it is contained in a company’s articles or in any contract with a company.”
 
     “Part IX, § 309B: Qualifying third party indemnity provisions.
 
3

 
     (1) For the purposes of section 309A(4) a provision is a qualifying third party indemnity provision if it is a provision such as is mentioned in section 309A(3) in relation to which conditions A to C below are satisfied.
 
     (2) Condition A is that the provision does not provide any indemnity against any liability incurred by the director–
 
     (a) to the company, or
 
     (b) to any associated company.
 
     (3) Condition B is that the provision does not provide any indemnity against any liability incurred by the director to pay –
 
     (a) a fine imposed in criminal proceedings, or
 
     (b) a sum payable to a regulatory authority by way of a penalty in respect of noncompliance with any requirement of a regulatory nature (however arising).
 
     (4) Condition C is that the provision does not provide any indemnity against any liability incurred by the director–
 
     (a) in defending any criminal proceedings in which he is convicted, or
 
     (b) in defending any civil proceedings brought by the company, or an associated company, in which judgment is given against him, or
 
     (c) in connection with any application under any of the following provisions in which the court refuses to grant him relief, namely –
 
     (i) section 144(3) or (4) (acquisition of shares by innocent nominee), or
 
     (ii) section 727 (general power to grant relief in case of honest and reasonable conduct).
 
     (5) In paragraph (a), (b) or (c) of subsection (4) the reference to any such conviction, judgment or refusal of relief is a reference to one that has become final.
 
     (6) For the purposes of subsection (5) a conviction, judgment or refusal of relief becomes final –
 
     (a) if not appealed against, at the end of the period for bringing an appeal, or
 
     (b) if appealed against, at the time when the appeal (or any further appeal) is disposed of.
 
     (7) An appeal is disposed of –
 
     (a) if it is determined and the period for bringing any further appeal has ended, or
 
     (b) if it is abandoned or otherwise ceases to have effect.
 
     (8) In this section “associated company” and “provision” have the same meaning as in section 309A.”
 
     “Part IX, § 309C: Disclosure of qualifying third party indemnity provisions.
 
     (1) Subsections (2) and (3) impose disclosure requirements in relation to a directors’ report under section 234 in respect of a financial year.
 
     (2) If –
 
4

 
     (a) at the time when the report is approved under section 234A, any qualifying third party indemnity provision (whether made by the company or otherwise) is in force for the benefit of one or more directors of the company, or
 
     (b) at any time during the financial year, any such provision was in force for the benefit of one or more persons who were then directors of the company,
 
the report must state that any such provision is or (as the case may be) was so in force.
 
     (3) If the company has made a qualifying third party indemnity provision and –
 
     (a) at the time when the report is approved under section 234A, any qualifying third party indemnity provision made by the company is in force for the benefit of one or more directors of an associated company, or
 
     (b) at any time during the financial year, any such provision was in force for the benefit of one or more persons who were then directors of an associated company, the report must state that any such provision is or (as the case may be) was so in force.
 
     (4) Subsection (5) applies where a company has made a qualifying third party indemnity provision for the benefit of a director of the company or of an associated company.
 
     (5) Section 318 shall apply to –
 
     (a) the company, and
 
     (b) if the director is a director of an associated company, the associated company,
 
as if a copy of the provision, or (if it is not in writing) a memorandum setting out its terms, were included in the list of documents in section 318(1).
 
     (6) In this section –
 
     “associated company” and “provision” have the same meaning as in section 309A; and
 
     “qualifying third party indemnity provision” has the meaning given by section 309B(1).”
 
     “Part XXV, § 727: Power of court to grant relief in certain cases.
 
     (1) If in any proceedings for negligence, default, breach of duty or breach of trust against an officer of a company or a person employed by a company as auditor (whether he is or is not an officer of the company) it appears to the court hearing the case that that officer or person is or may be liable in respect of the negligence, default, breach of duty or breach of trust, but that he has acted honestly and reasonably, and that having regard to all the circumstances of the case (including those connected with his appointment) he ought fairly to be excused for the negligence, default, breach of duty or breach of trust, that court may relieve him, either wholly or partly, from his liability on such terms as it thinks fit.
 
     (2) If any such officer or person as above-mentioned has reason to apprehend that any claim will or might be made against him in respect of any negligence, default, breach of duty or breach of trust, he may apply to the court for relief; and the court on the application has the same power to relieve him under this section as it would have had if it had been a court before which proceedings against that person for negligence, default, breach of duty or breach of trust had been brought.
 
     (3) Where a case to which subsection (1) applies is being tried by a judge with a jury, the judge, after hearing the evidence, may, if he is satisfied that the defendant or defender ought in pursuance of that subsection to be relieved either in whole or in part from the liability sought to be enforced against him, withdraw the case in whole or in part from the jury and forthwith direct judgment to be entered for the defendant or defender on such terms as to costs or otherwise as the judge may think proper.”
 
5

 
Item 7.  Exemption from Registration Claimed.
 
Not applicable.
 
Item 8.  Exhibits.
 
Exhibit Number
   
4.1
 
Form of Deposit Agreement dated as of June 1, 1993, among the Company, Morgan Guaranty Trust Company of New York, as depositary, and the holders from time time of American Depositary Receipts (“ADRs”), including the form of ADR attached hereto as Exhibit A. (Incorporated by reference to Exhibit 2.4 [as incorporated therein by reference to 1933 Act File No. 33-61406] to the Form 8-A/A registration statement of the Company filed under the Exchange Act; see File No. 1-11960)
     
5
 
Opinion of Ann Booth-Barbarin
     
23.1
 
Consent of KPMG, independent auditors
     
23.2
 
Consent of Ann Booth-Barbarin (included in Exhibit 5)
     
24
 
Power of Attorney (included in the signature pages hereof)
     
99.1
 
AstraZeneca Share Option Plan
     
99.2
 
AstraZeneca Restricted Share Plan
     
99.3
 
AstraZeneca Performance Share Plan
     
99.4
 
AstraZeneca Deferred Bonus Plan
     
99.5
 
AstraZeneca Pharmaceuticals LP 2007 Restricted Stock Unit Award Plan
     
99.6
 
AstraZeneca Pharmaceuticals LP Executive Performance Share Plan
     
99.7
 
MedImmune, Inc. 2008 Restricted Stock Unit Award Plan

Item 9.  Undertakings.
 
(a)    The undersigned Registrant hereby undertakes:
 
(1)   To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:
 
(i)      To include any prospectus required by Section 10(a)(3) of the Securities Act;
 
(ii)     To reflect in the prospectus any facts or events arising after the effective date of this Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this Registration Statement;
 
(iii)    To include any material information with respect to the Plan not previously disclosed in this Registration Statement or any material change to such information in this Registration Statement;
 
6

 
provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in periodic reports filed by the Registrant pursuant to Section 13 or 15(d) of the Exchange Act that are incorporated by reference in this Registration Statement.
 
(2)   That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
 
(3)   To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
 
(4)   That, for the purpose of determining liability under the Securities Act to any purchaser:
 
(i) If the Company is relying on Rule 430B:
 
(A)      Each prospectus filed by the Company pursuant to Rule 424(b)(3) shall be deemed to be part of the registration statement as of the date the filed prospectus was deemed part of and included in the registration statement; and

(B) Each prospectus required to be filed pursuant to Rule 424(b)(2), (b)(5), or (b)(7) as part of a registration statement in reliance on Rule 430B relating to an offering made pursuant to Rule 415(a)(1)(i), (vii), or (x) for the purpose of providing the information required by section 10(a) of the 1933 Act shall be deemed to be part of and included in the registration statement as of the earlier of the date such form of prospectus is first used after effectiveness or the date of the first contract of sale of 314 securities in the offering described in the prospectus. As provided in Rule 430B, for liability purposes of the issuer and any person that is at that date an underwriter, such date shall be deemed to be a new effective date of the registration statement relating to the securities in the registration statement to which that prospectus relates, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. Provided, however, that no statement made in a registration statement or prospectus that is part of the registration statement or made in a document incorporated or deemed incorporated by reference into the registration statement or prospectus that is part of the registration statement will, as to a purchaser with a time of contract of sale prior to such effective date, supersede or modify any statement that was made in the registration statement or prospectus that was part of the registration statement or made in any such document immediately prior to such effective date; or
 
 (ii) If the Company is subject to Rule 430C, each prospectus filed pursuant to Rule 424(b) as part of a registration statement relating to an offering, other than registration statements relying on Rule 430B or other than prospectuses filed in reliance on Rule 430A, shall be deemed to be part of and included in the registration statement as of the date it is first used after effectiveness. Provided, however, that no statement made in a registration statement or prospectus that is part of the registration statement or made in a document incorporated or deemed incorporated by reference into the registration statement or prospectus that is part of the registration statement will, as to a purchaser with a time of contract of sale prior to such first use, supersede or modify any statement that was made in the registration statement or prospectus that was part of the registration statement or made in any such document immediately prior to such date of first use.
 
(5) That, for the purpose of determining liability of the Company under the 1933 Act to any purchaser in the initial distribution of the securities, the undersigned Company undertakes that in a primary offering of securities of the undersigned Company pursuant to this Registration Statement, regardless of the underwriting method used to sell the securities to the purchaser, if the securities are offered or sold to such purchaser by means of the following communication, the undersigned Company will be a seller to the purchaser and will be considered to offer or sell such securities to such purchaser:
 
7

 
 (i)  any preliminary prospectus or prospectus of the undersigned Registrant relating to the offering required to be filed pursuant to Rule 424;

(ii) any free writing prospectus relating to the offering prepared by or on behalf of the undersigned  Company or used or referred to by the undersigned Company;
 
(iii)  the portion of any other free writing prospectus relating to the offering containing material information about the undersigned Company or its securities provided by or on behalf of the undersigned Company; and
 
(iv) any other communication that is an offer in the offering made by the undersigned Company to the purchaser.
 
(b)    The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant’s annual report pursuant to Section 13(a) or 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan’s annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
 
(c)    Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable.  In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.
 
8

 
SIGNATURES
 
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant, AstraZeneca PLC, certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Wilmington, Delaware, on the 5th day of August, 2008.
 
    AstraZeneca PLC  
           
    By: /s/ Ann Booth-Barbarin  
      Name:   
Ann Booth-Barbarin, Esq.
 
     
Title:
Senior Counsel and Assistant Secretary  
 
9

 
POWER OF ATTORNEY

Know all men by these presents that each person whose signature appears below, constitutes and appoints Graeme Harold Rankine Musker, Glenn M. Engelmann, and Ann Booth-Barbarin and each of them, our true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution, to do any all acts and things and execute, in the name of the undersigned, any and all instruments which said attorneys-in-fact and agents may deem necessary or advisable in order to enable AstraZeneca PLC to comply with the Securities Act of 1933, as amended (the “1933 Act), and any requirements of the Securities and Exchange Commission (the “Commission”) in respect thereof, in connection with the filing with the Commission of a Registration Statement under the 1933 Act, with respect to the increase in the shares to be registered under the AstraZeneca Share Option Plan, and the AstraZeneca Executive Performance Share Plan, and the approval of the AstraZeneca Pharmaceuticals LP 2007 Restricted Stock Unit Award Plan, including specifically but without limitation, power and authority to sign the name of the undersigned to such registration statement, and any amendments to such Registration Statement (including post-effective amendments), and to file the same with all exhibits thereto and other documents in connection therewith, the Commission, to sign any and all applications, registration statements, notices or other documents necessary or advisable to comply with applicable state securities laws, and to file the same, together with other documents in connection therewith with the appropriate state securities authorities, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and to perform each and every act and thing requisite or necessary to be done in and about the premises, as fully and to all intents and purposes as the undersigned might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, and any of them, or their substitutes, may lawfully do or cause to be done by virtue hereof.
 
Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the following capacities on the dates shown.

10

 
Signature
   
Title
 
Date
           
/s/ David R. Brennan
   
Executive Director – Chief Executive (Principal Executive Officer)
 
8/5/08
David R. Brennan
         
           
/s/ Simon Lowth
   
Executive Director – Chief Financial Officer (Principal Financial Officer)
 
8/5/08
Simon Lowth
         
           
           
 s/  John Patterson          
John Patterson
   
Executive Director
 
8/5/08
           
           
/s/ Louis Schweitzer
   
Non-Executive Chairman
 
8/5/08
 Louis Schweitzer          
           
           
/s/ Håkan Mogren
   
Non-Executive Deputy Chairman
 
8/5/08
Håkan Mogren 
         
           
           
/s/ Jane Henney
   
Non-Executive Director
 
8/5/08
Jane Henney
         
           
           
/s/ Marcus Wallenberg
   
Non-Executive Director
 
8/5/08
Marcus Wallenberg
         
           
           
/s/ Michele Hooper
   
Non-Executive Director
 
8/5/08
Michele Hooper
         
           
           
/s/ John Varley
   
Director
 
8/5/08
John Varley
         
           
           
/s/ Nancy Rothwell
   
Director
 
8/5/08
Nancy Rothwell
         
 
11

 
POWER OF ATTORNEY

Know all men by these presents that each person whose signature appears below, constitutes and appoints Graeme Harold Rankine Musker, Glenn M. Engelmann, and Ann Booth-Barbarin and each of them, our true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution, to do any all acts and things and execute, in the name of the undersigned, any and all instruments which said attorneys-in-fact and agents may deem necessary or advisable in order to enable AstraZeneca PLC to comply with the Securities Act of 1933, as amended (the “1933 Act), and any requirements of the Securities and Exchange Commission (the “Commission”) in respect thereof, in connection with the filing with the Commission of a Registration Statement under the 1933 Act, with respect to the approval of the MedImmune, Inc. 2008 Restricted Stock Unit Award Plan, the AstraZeneca Performance Share Plan, the AstraZeneca Restricted Share Plan and the AstraZeneca Deferred Bonus Plan and the number of shares needed to be registered for issuance to US participants under these plans, including specifically but without limitation, power and authority to sign the name of the undersigned to such registration statement, and any amendments to such Registration Statement (including post-effective amendments), and to file the same with all exhibits thereto and other documents in connection therewith, the Commission, to sign any and all applications, registration statements, notices or other documents necessary or advisable to comply with applicable state securities laws, and to file the same, together with other documents in connection therewith with the appropriate state securities authorities, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and to perform each and every act and thing requisite or necessary to be done in and about the premises, as fully and to all intents and purposes as the undersigned might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, and any of them, or their substitutes, may lawfully do or cause to be done by virtue hereof.
 
Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the following capacities on the dates shown.

12

 
Signature
   
Title
 
Date
           
/s/ David R. Brennan
   
Executive Director – Chief Executive (Principal Executive Officer)
 
8/5/08
David R. Brennan
         
 
         
/s/ Simon Lowth
   
Executive Director – Chief Financial Officer (Principal Financial Officer)
 
8/5/08
Simon Lowth
         
           
           
/s/  John Patterson
   
Executive Director
 
8/5/08
John Patterson
         
           
           
/s/ Louis Schweitzer
   
Non-Executive Chairman
 
8/5/08
Louis Schweitzer
         
           
           
/s/ Håkan Mogren
   
Non-Executive Deputy Chairman
 
8/5/08
Håkan Mogren
         
           
           
/s/ Jane Henney
   
Non-Executive Director
 
8/5/08
Jane Henney
         
           
           
/s/ Marcus Wallenberg
   
Non-Executive Director
 
8/5/08
Marcus Wallenberg
         
           
           
/s/ Michele Hooper
   
Non-Executive Director
 
8/5/08
Michele Hooper
         
           
           
/s/ John Buchanan
   
Non-Executive Director
 
8/5/08
John Buchanan
         
           
           
/s/ Jean-Phillipe Courtois
   
Non-Executive Director
 
8/5/08
 Jean-Phillipe Courtois          
           
           
/s/ John Varley
   
Director
 
8/5/08
John Varley
         
           
           
/s/ Nancy Rothwell
   
Director
 
8/5/08
Nancy Rothwell
         
           
           
/s/ Bo Angelin
   
Director
 
8/5/08
Bo Angelin
         
 
13

 
EXHIBIT INDEX1
 

Exhibit Number
   
4.1
 
Form of Deposit Agreement dated as of June 1, 1993, among the Company, Morgan Guaranty Trust Company of New York, as depositary, and the holders from time to time of American Depositary Receipts (“ADRs”), including the form of ADR attached hereto as Exhibit A. (Incorporated by reference to Exhibit 2.4 [as incorporated therein by reference to 1933 Act File No. 33-61406] to the Form 8-A/A registration statement of the Company filed under the Exchange Act; see File No. 1-11960)
     
5
 
Opinion of Ann Booth-Barbarin
     
23.1
 
Consent of KPMG, independent auditors
     
23.2
 
Consent of Ann Booth-Barbarin (included in Exhibit 5)
     
24
 
Power of Attorney (included in the signature pages hereof)
     
99.1
 
AstraZeneca Share Option Plan
     
99.2
 
AstraZeneca Restricted Share Plan
     
99.3
 
AstraZeneca Performance Share Plan
     
99.4
 
AstraZeneca Deferred Bonus Plan
     
99.5
 
AstraZeneca Pharmaceuticals LP 2007 Restricted Stock Unit Award Plan
     
99.6
 
AstraZeneca Pharmaceuticals LP Executive Performance Share Plan
     
99.7
 
MedImmune, Inc. 2008 Restricted Stock Unit Award Plan
 

1 Should be identical to prior list of exhibits
 
 
14
 

 
 
EXHIBIT 5
 
[Letterhead of Legal Counsel AstraZeneca]
 
August 4, 2008

Securities and Exchange Commission
100 F Street, NW
Washington, D.C. 20549
 
Dear Sirs:
 
In connection with this Registration Statement on Form S-8 (the “Registration Statement”) to register under the Securities Act of 1933, as amended, 58,195,000 American Depositary Receipts of the Company’s common stock, par value £0.25 per share (the “Shares”), deliverable pursuant to the AstraZeneca Share Option Plan, Restricted Share Plan, Performance Share Plan, Deferred Bonus Plan, Pharmaceuticals LP Executive Performance Share Plan, Pharmaceuticals LP 2007 Restricted Stock Unit Award Plan and MedImmune, Inc. 2008 Restricted Stock Unit Award Plan (the “Plans”), I have examined originals or copies, certified or otherwise identical to my satisfaction of such documents, corporate records, certificates of public officials and other instruments as I have deemed necessary for the purpose of this opinion.
 
Upon the basis of the foregoing, I am of the opinion that the Shares, when delivered in accordance with the Plans upon receipt by the Company of adequate consideration therefor, will be validly issued, fully paid and nonassessable.
 
We consent to the filing of this opinion as an exhibit to the Registration Statement.

 
 
Very truly yours,
   
  /s/ Ann Booth-Barbarin
 
Ann Booth-Barbarin
  Senior Counsel and Assistant Secretary
 


 
 
 


EXHIBIT 23.1




CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
 
The Board of Directors
AstraZeneca PLC

We consent to the use of our reports dated January 31, 2008, with respect to the consolidated balance sheets of AstraZeneca PLC as of December 31, 2007, 2006 and 2005, and the related consolidated income statements, consolidated statements of recognised income and expense, and consolidated cash flow statements for each of the years in the three-year period ended December 31, 2007, and the effectiveness of internal control over financial reporting as of December 31, 2007, incorporated herein by reference.
­­­­­­­­­­
/s/ KPMG Audit Plc
 
KPMG Audit Plc, London
 
31 July 2008
 

 
 
 
 


Exhibit 99.1
 
 
AstraZeneca PLC
 


________________________________________________________________


THE ASTRAZENECA SHARE OPTION PLAN


__________________________________________________________________






As adopted by the Board of Directors of the Company and approved by the Company in general meeting on 26 May 2000

Amended:
24 July 2002 (new exercise process changes)
3 October 2002 (French schedule)









  THE ASTRAZENECA SHARE OPTION PLAN

  CONTENTS
 

 
 
 
Page
1.
The AstraZeneca Share Option Plan
 
     
     
 
1.
How the Plan will operate
1
       
 
2.
Performance targets
2
       
 
3.
The limit on the number of Shares which can be issued
2
       
 
4.
The exercise of Options
4
       
 
5.
Cessation of Employment
4
       
 
6.
Lapse of Options
5
       
 
7.
General offer, scheme of arrangement or voluntary winding-up of the Company
6
       
 
8.
How Options are exercised
8
       
 
9.
Adjustment of Options
9
       
 
10.
Exchange of Options
10
       
 
11.
Amending the Plan
11
       
  12. General  12
 
 
US Appendix
15
     
 
Canadian Appendix
21
     
 
Schedule 1 (France)
21
     
 
Schedule 2 (The Netherlands)
22
     
 
Schedule 3 (Japan)
25
     
 
Schedule 4 (Puerto Rico)
26
     
 
Schedule 5 (Belgium)
27
     
 
Definitions Appendix
28
     
   
Page
     
2.
The AstraZeneca Inland Revenue Approved Share Option Plan
 
 
 
1.
How the Approved Plan will operate
33
 

 
 
 
2.
Performance targets
34
       
 
3.
The limit on the number of Shares which can be issued
35
       
 
4.
The exercise of Options
36
       
 
5.
Lapse of Options
37
       
 
6.
Discretion to extend period of exercise
38
       
 
7.
General offer, scheme of arrangement or voluntary winding-up of the Company
39
       
 
8.
How Options are exercised
40
       
 
9.
Adjustment of Options
41
       
 
10.
Exchange of Options
42
       
 
11.
Amending the Approved Plan
43
       
 
12.
General
44
       
  Definitions Appendix
47

 



  RULES OF THE ASTRAZENECA SHARE OPTION PLAN

1.           HOW THE PLAN WILL OPERATE

1.1
Policies set by the Remuneration Committee

 
The Remuneration Committee will set the policies for the Company’s operation and administration of the Plan within the terms of the Rules, including as regards:

1.1.1
the Eligible Employees who will be eligible to participate from time to time;

1.1.2
the maximum Market Value of Shares which may be put under any Eligible Employee’s Option;

1.1.3
what Option Price will apply to each Eligible Employee’s Option;

1.1.4
whether any performance target(s) will apply to the grant and/or exercise of each Eligible Employee’s Option;

1.1.5
how Options are granted; and

1.1.6
the extent to which Options may be exercised when Participants cease Employment.
     
The Remuneration Committee can change any of its policies at any time but it cannot change its policies to the detriment of a Participant’s subsisting Options.


1.2
Participation and the grant of Options

An Eligible Employee may be recommended from time to time for the grant of an Option.  Options will be granted by the Company in accordance with the Rules.  Alternatively, the Company may request the Trustee to grant the Option or agree to satisfy the exercise of any Option granted in accordance with the Rules.  Options will be granted by deed.  A single deed of grant can be executed in favour of any number of Eligible Employees.

1.3
The Option Price

 
An Option will be granted at the Option Price determined by the Remuneration Committee in accordance with the Rules.
 
1

 

 
1.4
When Options will be granted

 
An Option can be granted at any time provided that the Date of Grant of an Option is not during a Close Period. After the fifth anniversary of the approval of the Plan by the Company in general meeting, no Option can be granted until the Remuneration Committee has reviewed the Plan.

1.5
Confirmation that an Option has been granted

 
A Participant who has been granted an Option will be sent, as soon as administratively practicable, an Option certificate confirming the grant of the Option and the terms on which it is granted.

1.6
An Option is personal to the Participant

 
An Option cannot be transferred, assigned, charged or otherwise disposed of. On the death of a Participant, his Option can be transmitted to his personal representatives.

1.7
An Option is subject to the Rules but may be renounced

 
An Option is granted incorporating and subject to the Rules.  A Participant may renounce his Option, in whole or in part, within 30 days of the Date of Grant and, to the extent renounced, the Option will be treated as if it had never been granted.

2.
PERFORMANCE TARGETS

2.1
Performance targets on grant or exercise of an Option

 
The grant or exercise of an Option may be subject to a performance target selected by the Remuneration Committee which, in the case of a performance target on exercise, will normally have to be met before the Option can be exercised. The exercise of an Option can be subject to any additional terms and conditions the Remuneration Committee considers appropriate.  If an Option is subject to any performance target or any additional terms and conditions, these will be specified at the Date of Grant.  Where an Option has been granted subject to a performance target, the Remuneration Committee will have complete discretion to decide whether and to what extent the performance target has been met.

2.2
Different performance targets can apply to different Eligible Employees

 
Options can be subject to different performance targets for each Eligible Employee.
 
 
2


 
3.
THE LIMIT ON THE NUMBER OF SHARES WHICH CAN BE  ISSUED

3.1
The limit for all Shares issued under the Plan

The number of Shares which can be allocated under the Plan on any day, when aggregated with the number of Shares allocated under the Approved Plan and any other Employees’ Share Scheme adopted by the Company in the previous 10 years, cannot exceed 10 per cent of the ordinary issued share capital of the Company from time to time.

3.2
Meaning of allocation and exclusion from these limits

The references in these Rules to the “allocation” of Shares mean, in the case of any share option plan, the placing of unissued Shares under option and, in relation to any other Employees’ Share Schemes, the issue and allotment of Shares.  For the purposes of the limit in Rule 3:

3.2.1
Shares where the right to acquire such Shares was released, cancelled or lapsed without being exercised will be ignored; and

3.2.2
to the extent that the exercise of Options is to be satisfied by the transfer of Shares already in issue, those Options will not be treated as granted over unissued Shares.

3.3
Adjustment to Shares to be taken into account

Where Shares issued under the Plan or any other Employees’ Share Scheme of the Company are to be taken into account for the purposes of any of the limits in this Rule 3 and a Variation in the equity share capital of the Company has taken place between the date of issue of any such Shares and the date on which any such limit is to be calculated, the number of such Shares which will be taken into account for the purposes of any such limit will be adjusted in such manner as the Remuneration Committee considers appropriate to take account of the Variation.

3.4          The individual limit

A limit on the Market Value (at the Date of Grant) of Shares which may put under Option on an annual basis in respect of any Eligible Employee will be set from time to time by the Remuneration Committee.  No Option will be granted to an Eligible Employee in excess of this limit without the prior approval of the Remuneration Committee.

3.5           Purported grant of an Option in excess of limits

If an Option is purported to be granted on terms which do not comply with Rule 3, the number of Shares over which that Option has been granted will,
 
3

 
with the number of Shares over which all other Options have been granted on the same Date of Grant, be reduced pro rata to the largest lower number as would comply with Rule 3. In any case where this Rule 3.5 operates, when the number of Shares under the Option has been adjusted accordingly, an Option will take effect from the Date of Grant as if it had been granted on the adjusted terms.

4           THE EXERCISE OF OPTIONS

4.1
When an Option can be exercised

 
Subject to Rule 4.2 (if appropriate) and to Rule 5.2, Rule 5.3, Rule 5.4 and Rule 7, an Option shall first be exercisable (in whole or in part) at any time following the third anniversary of the Date of Grant of that Option.

4.2
Satisfaction of any performance target

 
An Option can only be exercised:-
 
4.2.1
if it was subject to a performance target, if that performance target has been satisfied, unless the performance target is, at the discretion of the Remuneration Committee, waived; and

4.2.2 
in accordance with any additional terms and conditions to which an Option is subject.

5.
CESSATION OF EMPLOYMENT

5.1
Normal provision

If a Participant ceases to be in Employment he will, subject to Rule 5.2, Rule 5.3 and Rule 5.4, cease to be entitled to exercise any Option on the day he so ceases.

5.2
Specific circumstances of cessation of Employment

If a Participant ceases to be in Employment because of:

5.2.1.
injury or disability;
 
5.2.2.
Redundancy;
 
5.2.3.
retirement;
 
5.2.4.
the company in the Group which employs him ceasing to be a Participating Company or an Associated Company or because of the transfer or sale of the undertaking (or part of the undertaking) in
 
4

 
 
 
which he is employed to a person who is neither a Participating Company nor an Associated Company;
 
5.2.5.
any of the circumstances described in Rule 7 (general offers, scheme of arrangement or voluntary winding-up of the Company) arising; or
 
5.2.6.
his death
 
 
all the Participant’s Options will, subject to Rule 4.2 and the proviso in Rule 7.4, become immediately exercisable.


5.3
Ceasing to be in Employment in other circumstances

If a Participant gives or is given notice to leave Employment or ceases to be in Employment without any notice having been given in any circumstances other than the ones referred to in Rule 5.2:

 
5.3.1
the Participant’s Options which are already exercisable must, if they are to be exercised, be exercised before the date on which the Participant ceases Employment; and
 
 
5.3.2
the Participant’s Options which are not yet exercisable can only be exercised if the Remuneration Committee decides to exercise its discretion to allow those Options to be exercised.
 
If the Remuneration Committee does decide to exercise its discretion under this Rule, it may do so on whatever basis it decides, subject to Rule 5.5.  It must notify the Participant (and, if appropriate, the Trustee) as soon as reasonably practicable, and must confirm the date by which the Option will lapse to the extent not exercised by that date.

5.4
Change of circumstances of Employment – deferral of exercise and lapse provisions

If a Participant ceases to be in Employment but continues to provide services to the Group or becomes employed by an Associated Undertaking, the Remuneration Committee can decide that the Participant is deemed not to have ceased Employment and that his Options will continue to be held subject to the Rules, so that Rule 5 will apply when he subsequently ceases to provide services to the Group or when he ceases to be employed by an Associated Undertaking and is not re-employed by a member of the Group, or in such other circumstances as the Remuneration Committee considers appropriate.
 
5

 

 
5.5
No exercise after the tenth anniversary of the Date of Grant

Rule 5 can never be used to allow a Participant to exercise his Option after the tenth anniversary of the Date of Grant.

6.           LAPSE OF OPTIONS

6.1
When Option lapses

 
An Option will lapse to the extent that it has not been exercised (whether or not it became exercisable) on the earliest of:

6.1.1.
normal lapse time:  the tenth anniversary of the Date of Grant;

6.1.2.
injury, disability, Redundancy, retirement etc: if the Participant ceases Employment for any of the reasons referred to in Rule 5.2.1, 5.2.2, 5.2.3 or 5.2.4, the date which is twenty four months from the date he so ceases Employment;

6.1.3.
cessation of Employment under Rule 5.3:  if a Participant ceases Employment under Rule 5.3, the date of cessation of Employment and if the Remuneration Committee  exercises its discretion under Rule 5.3.2, the date specified by the Remuneration Committee;
 
6.1.4.
general offers, schemes of arrangement or voluntary winding-up of Company:  without prejudice to the operation of Rule 10, the expiry of the applicable period referred to in Rule 7.1, Rule 7.3, Rule 7.4 (subject to the proviso in Rule 7.4)or Rule 7.5; and

6.1.5.
insolvency:  the date on which a Participant enters into a composition with his creditors in satisfaction of his debts or a bankruptcy order is made against him.

6.2
Death

 
If a Participant dies at any time when any Option granted to him is outstanding, the Option will be and remain capable of exercise until the expiry of twenty four months from the date of his death.

6.3
Avoidance of lapse of Options where Rule 7 applies

An Option will not lapse under Rule 6.1.2 or Rule 6.1.3 if the Option would lapse under any of those provisions in a period when the Option is capable of being exercised under Rule 7, although the Option will lapse at the end of the period applicable under Rule 7.  This Rule is subject to Rule 6.1.1.

6


6.4           Female Participants on maternity leave

For the purposes of this Rule 6, a female Participant on maternity leave will not cease to be in Employment until the earlier of the date on which she notifies her employer of her intention not to return to work or the date on which she ceases to have statutory or contractual rights to return to work.

7.
GENERAL OFFER, SCHEME OF ARRANGEMENT OR VOLUNTARY WINDING-UP OF THE COMPANY

7.1
General offer to acquire Shares

If an offeror (either alone or together with any party acting in concert with him) obtains Control of the Company as a result of a general offer to acquire the whole of the issued ordinary share capital of the Company (or such part of it which is not at the time owned by the offeror and any person acting in concert with the offeror or any such person) a Participant can, subject to Rule 6 and Rule 7.3, exercise his Option at any time during the period of six months following the date on which the offeror (together with any person acting in concert with him) obtained Control of the Company.  After that period, all unexercised Options will, without prejudice to the operation of Rule 10, lapse.

7.2
Extension to Participants of general offer

 
The Company will use its best endeavours to procure that if a Participant is allotted Shares pursuant to the exercise of his Option in accordance with Rule 7.1 and those Shares were not the subject of the general offer, the offeror will make an offer to acquire those Shares from the Participant on the same terms as Shares of the same class were acquired under the general offer.

7.3
Compulsory purchase of minority interest in the share capital of the Company

 
If any person becomes bound or entitled to give a notice under Sections 428 to 430F of the Companies Act 1985 to acquire any Shares (or would be so entitled but for the fact that there were no dissenting shareholders) each Participant will be notified of this as soon as possible.  A Participant can exercise his Option at any time while such person is so entitled.  After such person ceases to be so entitled, all unexercised Options (other than any New Option granted under Rule 10) will lapse.

7.4
Scheme of arrangement

 
If the court directs that a meeting of the holders of Shares should be convened under section 425 of the Companies Act 1985 to consider a scheme of arrangement, then:
 
7

 

 
7.4.1
a Participant’s Option will be exercisable, conditionally on the scheme of arrangement being sanctioned by the court, from the date of the court’s direction until midday on the day immediately before the date for which the shareholders’ meeting is convened and then, subject to the operation of Rule 10, shall lapse, if not exercised, on the date the scheme of arrangement is sanctioned by the court; and

7.4.2
the Board shall endeavor to procure that where the Participant has conditionally exercised his Option pursuant to Rule 7.4.1 above, the scheme of arrangement shall be extended to the Shares in respect of which the Option was conditionally exercised as if such Shares had been allotted and issued or transferred, as appropriate, to him by the  time the scheme of arrangement is sanctioned by the court

PROVIDED THAT, without prejudice to the operation of Rule 10, Options shall not, without the consent of the Board, be exercisable under this Rule if the purpose and effect of the scheme of arrangement is to create a new holding company for the Company, where such holding company would, following the scheme of arrangement, have substantially the same shareholders and proportionate shareholdings as those of the Company immediately prior to the scheme of arrangement.

7.5
Voluntary winding-up of the Company

 
At any time before a resolution for a member’s voluntary winding-up of the Company (of which each Participant must be given notice) is passed, a Participant may exercise his Option conditionally on the resolution being passed.  If such a resolution is passed, all Options will immediately lapse to the extent that they have not been exercised.

8.           HOW OPTIONS ARE EXERCISED

8.1
Notice of exercise must be given

 
An Option will be exercised when the Participant delivers to theTrustee (or its agent):

8.1.1
a notice of exercise in such form and manner specified by theCompany; and
 
8.1.2
evidence to the satisfaction of the Trustee (or its agent) that it has received or will receive as soon as practicable payment in full of the Option Price for the aggregate number of Shares over which the Option is purported to be exercised.
 
The Participant may be permitted by the Company to pay the Option Price in a currency other than that in which the Option was granted, on the basis of such arrangements agreed by the Company.  The exercise is not effective until
 
8

 
the Company (or its agent) is satisfied that all the necessary documentation, payments and/or information has been provided.
 
In any case where the exercise of the Option is to be satisfied by the Company and not the Trustee, references in this Rule 8.1 to the Trustee shall be taken to refer to the Company.
 
8.2
Options exercisable in whole or in part
 
An Option may be exercised in whole or in part.   If an Option is exercised in part, it may not be exercised (except to the full extent outstanding) except in multiples of 100 Shares or such other multiple as is determined by the Remuneration Committee from time to time.

8.3
Payment of taxes etc.

The exercise of an Option is subject to the Company being satisfied that any withholdings that may be necessary on account of a Participant’s Tax Liability in respect of the Option can be made.  Unless the Participant makes arrangements with the Company to provide payment in respect of his Tax Liability, the Participant agrees that the Company or any relevant company in the Group can sell on behalf of the Participant such number of Shares acquired on the exercise of an Option as is necessary to discharge the Tax Liability.

8.4
What a Participant gets when he has exercised

 
Subject to Rule 8.5, the Company will allot or procure the transfer of the Shares in respect of which the Option has been exercised to the Participant or his nominee, less any Shares sold under Rule 8.3, within 30 days following the date of exercise of the Option.

8.5.
Consents and approvals

 
The allotment or transfer of Shares under the Plan is subject to obtaining any approval or consent required.    The Company will, if appropriate, apply to the London Stock Exchange for Shares issued under the Plan to be admitted to the Official List (unless listing has already been granted).

8.6
Ranking of Shares

 
Shares allotted or transferred to a Participant under the Plan will rank equally in all respects with Shares of the same class. However, they will not be entitled to any rights attaching to Shares by reference to a record date falling before the date of exercise of the Option.
 
9

 

 
9.
ADJUSTMENT OF OPTIONS

9.1
Variation in equity share capital

 
If there is a Variation in the equity share capital of the Company:

9.1.1
the number and/or the nominal value of Shares over which an Option is granted; and/or

9.1.2
the Option Price; and/or

9.1.3
where an Option has been exercised but at the date of the Variation no Shares have been allotted or transferred pursuant to such exercise, the number of Shares which may be so allotted or transferred and the Option Price

 
may be adjusted by the Remuneration Committee in such manner as it considers appropriate so that (as nearly as may be without involving fractions of a Share or an Option Price calculated to more than two decimal places) the aggregate Option Price of an Option will be the same.

9.2
Nominal value of Shares

 
Apart from under this Rule 9.2, no adjustment under Rule 9.1 can have the effect of reducing the Option Price to less than the nominal value of a Share.  Where an Option subsists over both issued and unissued Shares, any such adjustment may only be made if the reduction of the Option Price in respect of both the issued and the unissued Shares can be made to the same extent.  Any adjustment made to the Option Price of Options over unissued Shares shall only be made if and to the extent that the Board will be authorised to:

9.2.1
capitalise from the reserves of the Company a sum equal to the amount by which the nominal value of the Shares in respect of which the Option is exercisable exceeds the adjusted aggregate Option Price;  and

9.2.2
apply such sum in paying up such amount on such Shares so that on exercise of any Option in respect of which such a reduction shall have been made the Board shall capitalise such sum (if any) and apply the same in paying up such amount.

9.3
Participants notified of adjustments

 
Participants will be notified of any adjustment made under this Rule 9 so that their Option certificates or deeds of grant can be called in or cancelled and re-issued.
 
10

 

10.
EXCHANGE OF OPTIONS

10.1
The Acquiring Company

 
If any company (the “Acquiring Company"):

10.1.1
obtains Control of the Company as a result of making a general offer to acquire:

 
(i)
the whole of the issued ordinary share capital of the Company which is made on condition such that if it is satisfied the Acquiring Company will have Control of the Company; or

 
(ii)
all the shares in the Company which are of the same class as the Shares;

in either case ignoring any Shares which are already owned by it or any member of the same group of companies; or

10.1.2
obtains Control of the Company in pursuance of a compromise or arrangement sanctioned by the court under Section 425 of the Companies Act 1985; or

10.1.3
becomes bound or entitled to acquire Shares under Sections 428 to 430F of that Act;

any Participant can, at any time within the Appropriate Period, by agreement with the Acquiring Company, release any Option which has not lapsed ("the Old Option ") in consideration of the grant to him of an Option ("the New Option ") which is equivalent to the Old Option but relates to shares in a different company.

10.2
The New Option

The New Option will not be regarded for the purposes of Rule 10.1 as equivalent to the Old Option unless the conditions set out in Paragraph 15(3) of Schedule 9 to the Taxes Act are satisfied, but so that the provisions of the Plan will, for this purpose, be construed as if the New Option were an option granted under the Plan at the same time as the Old Option.  References to Shares will, in relation to the New Option, be taken as references to shares of the company whose shares are scheme shares.  References to the Company shall, in relation to the New Option, be taken to be references to the company whose shares are scheme shares, where appropriate.  The New Options do not lapse if Rule 7 applies following the event permitting the grant of such new rights.

11



11.
AMENDING THE PLAN

11.1
The Board has discretion to amend the Rules

 
Subject to the rest of this Rule 11, the Board can amend the Rules of the Plan at any time by resolution.

11.2
Additional sections

 
The Company can adopt additional sections of the Rules applicable in any jurisdiction under which Options may be subject to additional and/or modified terms and conditions, having regard to any securities, exchange control or taxation laws, which may apply to the Participant, the Company, any Participating Company or Associated Company. Any additional sections must conform to the basic principles of the Plan and must not enlarge to the benefit of Participants the limits in the Rules.

11.3
No abrogation of existing rights

 
No amendment will be made under Rule 11.1 which would abrogate or materially affect adversely the existing rights of a Participant unless it is made with his written consent or by a resolution passed as if the Options constituted a separate class of share capital and the provisions of the Articles of Association of the Company and of the Companies Act 1985 relating to class meetings (with the necessary amendments) applied to that class.

11.4
Shareholder approval

 
No amendment to the advantage of Participants or Eligible Employees (except for an amendment which could be included in an additional section adopted under Rule 11.2) can be made to the provisions in the Rules (if any) relating to:

11.4.1
who can be a Participant or Eligible Employees; and

11.4.2
the number of Shares which can be allocated under the Plan; and
 
11.4.3
the basis for determining a Participant’s entitlement to and the terms of the Shares and any adjustment in the event of a Variation;

 
without the approval by ordinary resolution of the Company in general meeting, except for minor amendments to benefit the administration of the Plan, to take account of a change in legislation or to obtain or maintain favourable tax, exchange control or regulatory treatment for Participants or Eligible Employees or for a member of the Group.

12



12.
GENERAL

12.1
Notices

Any notice or other communication in connection with the Plan (including where permitted, Option certificates) can be given by electronic mail, by personal delivery, by post (in the case of a company, to its registered office and in the case of an individual to his last known address) or by any other means which a Participating Company and its employees use to communicate with each other.  Where a notice or other communication is given by post, it shall be deemed to have been received 72 hours after it was put into the post properly addressed and stamped.

12.2
Documents sent to shareholders

 
Participants may, but are not entitled to, receive copies of any notice or document sent by the Company to the holders of Shares.

12.3
Replacement Option certificates

 
If any Option certificate is worn out, defaced or lost, it can be replaced on such evidence being provided as may be required.

12.4
Administration of the Plan

 
The Plan will be administered in a manner approved by the Board .  No individual will have any authority in relation to the Plan unless that authority has been approved in accordance with the policy set by the Board.  The Company’s decision on any matter concerning the Plan or the interpretation of the Rules will be final and binding.

12.5
Costs of introducing and administering the Plan

 
The costs of introducing and administering the Plan will be borne by the Company.  However, the Company can require any Participating Company to enter into such arrangement to reimburse the Company for any costs borne by the Company directly or indirectly in respect of such Participating Company’s Participants.

12.6
Termination of the Plan

 
The Plan will terminate at the end of the Plan Period or at any earlier time the Board shall decide.  Termination of the Plan will not affect the subsisting rights of Participants.

13



12.7
Rights of Participants and Eligible Employees
 
Participation in the Plan is not pensionable.  Nothing in the Plan nor in any instrument executed pursuant to it will confer upon any person any right to continue in the employment of the Group, or will affect the right of the Company or any company in the Group to terminate the employment of any person without liability at any time with or without cause, or will impose upon the Group or the Board or their respective agents and employees any liability whatsoever (whether in contract, tort, or otherwise howsoever) in connection with:
 
12.7.1
the lapsing of any Option pursuant to the Rules;
 
12.7.2
the failure or refusal to exercise any discretion under the Rules; and/or
 
12.7.3
a Participant ceasing to be a person who has the status or relationship of an employee or executive director with the Company or any other company in the Group for any reason whatever as a result of the termination of the employment relationship with the Company or any other Group Member.

12.8
Waiver of any rights
 
 
Any person who ceases to have the status or relationship of an employee or executive director with the Company or any other company in the Group for any reason as a result of dismissal (lawfully or otherwise) shall not be entitled and shall be deemed irrevocably to have waived any entitlement by way of damages for dismissal or by way of compensation for loss of office or otherwise, to any sum, damages, Shares or other benefits to compensate that person for the loss of any rights, benefits or expectations under any Option, the Plan or any instrument executed pursuant to it.
 
12.9
The Benefit of Rules 12.7 and 12.8
 
The benefit of Rules 12.7 and 12.8 is given for the Company and/or the Trustee as appropriate for itself and as trustee and agent of the Company (if the benefit is given for the Trustee) and of all the Company’s Subsidiaries, Associated Companies and Associated Undertakings.  To the extent that the Company any Subsidiary, Associated Company or Associated Undertaking of the Company is not party to the grant of an Option, the Company and/or  Trustee, as appropriate, will hold the benefit of Rule 12.7 and Rule 12.8 on trust and as agent for each of them and the Company and/or Trustee may, at their respective discretion, assign the benefit of this Rule 12.9 to any of them.
 
14

 
 
12.10
Options  are subject to the Rules

 
Options are granted incorporating and subject to the Rules.

12.11
Articles of Association

 
Any Shares acquired on the exercise of Options are subject to the Articles of Association of the Company as amended from time to time.

12.12
Governing Law

 
The Rules are governed by and interpreted in accordance with the law of England.  Each Participant, the Company and any other Participating Company or Associated Company submits to the jurisdiction of the English courts in relation to anything arising under the Plan.
 
15

 

 
THE RULES OF THE ASTRAZENECA SHARE OPTION PLAN

U.S. APPENDIX


 
1.
This Appendix constitutes the part of the Plan that will govern the grant of Options to United States Participants (the “U.S. Options”) and incorporates all the Rules of the Plan (as set forth above) including as modified in accordance with the provisions of this  Appendix.
 
2.
How U. S. Options will be granted
 
All U.S. Options shall be evidenced by an instrument(s) in such form or forms as may from time to time be approved by the Company which, among other things, shall set forth the manner in which a Participant may exercise such U.S. Option and the form of payment for the Shares or ADSs issuable or transferable under it.
 
3.
Administration of the U.S. Appendix
 
The Company shall (i) administer the U.S. Appendix; (ii) establish from time to time such rules and regulations as it may deem appropriate for the proper administration of the U.S. Appendix; and (iii) make such determinations under, and such interpretations of, and take such actions in connection with, the U.S. Appendix or U.S. Options as it may deem necessary or advisable.
 
4.
Option Price
 
The definition of “Option Price” in the Definitions Appendix shall be deleted and replaced by the following:
 
 
“the arithmetical average of the closing prices of ADSs (as derived from the New York Stock Exchange Official List) on the three consecutive dealing days last preceding the Date of Grant rounded up to the nearest whole cent (or such other dealing day or days not preceding the day on which the Company last announced its results for any period as the Board may determine).”
 
5.
Exercise of Options
 
 
5.1
Rule 5.2.2. shall be amended so that the word “Redundancy” is deleted and replaced with the following:
 
 
“circumstances in which he is entitled to receive a severance payment under any severance program adopted by his employing company or under any change-in-control contract or employment agreement to which he is a party.”
 
 
5.2          Rule 5.2.3 shall be deleted in its entirety and replaced with the following:
 
16

 

 
“retirement at or after the date the Participant is eligible to receive an immediate retirement benefit under the defined benefit pension plan in which he is then actively participating  or, if the Participant participates in the AstraZeneca Retirement Plan, at or after the date he reaches age 55 and completes ten years of service with the Group;”

 
5.3
Rule 6.1.2 shall be amended so that the words “Redundancy” is deleted in the first line.
 
 
5.4
For the purposes of Rule 6, a Participant on leave of absence will not cease to be in Employment until the earlier of the date on which the Participant notifies his employer of his intention not to return to work or the date set by the employer for termination of the employment relationship pursuant to applicable leave of absence policies.
 
 
6.